Meaning of the surname Santiago
Santiago is a Spanish surname of the religious type meaning "Saint James". It is one of the 50 most common surnames in Mexico. A Church-given surname, common in Oaxaca and among indigenous families. Forty-seventh in Mexico.
Given at baptism or taken from the church calendar: Cruz (cross), Santos (saints), de la Cruz, Santiago, Reyes (kings, for Epiphany), Trinidad, Guadalupe.
In Mexico a person carries two surnames, the father's and then the mother's, so Santiago appears as either half of a pair: Santiago García, López Santiago. Read how the two-surname system works.